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The principal metabolites of paroxetine are polar and conjugated products of oxidation and methylation which are readily cleared.

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In addition, because ondansetron is a cyp2d6 substrate and has a possible risk of qt prolongation and torsade de pointes, concurrent use of a potent cyp2d6 inhibitor such as paroxetine may increase the risk of such events.

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The efficacy of paroxetine tablets, usp were established in two 12-week trials with obsessive compulsive outpatients whose diagnoses corresponded most closely to the dsm-iiir category of obsessive compulsive disorder see clinical pharmacology clinical trials .

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A randomised, double-blind, 24-week study comparing the efficacy and tolerability of mirtazapine and paroxetine in depressed patients in primary care.

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