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In vitro studies indicate that the major cytochrome p 450 isozyme involved in the metabolism of requip pd is cyp1a2, an enzyme known to be stimulated by smoking and omeprazole, and inhibited by, for example, fluvoxamine, mexiletine, and the older fluoroquinolones such as ciprofloxacin and norfloxacin.

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In controlled clinical trials, dizziness was a common adverse reaction in patients receiving requip and was more frequent in patients with parkinson s disease or with rls receiving requip than in patients receiving placebo early parkinson s disease without l-dopa requip 40 , placebo 22 ; advanced parkinson s disease requip 26 , placebo 16 ; rls requip 11 , placebo 5 .

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This side of the patient information leaflet summarizes the most important information about requip and requip xl for parkinson s disease.

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Ropinirole comes in an oral standard tablet and an extended-release tablet requip xl .

The most commonly observed adverse events 5 in the double-blind, placebo-controlled early parkinson s disease trials associated with the use of requip pd hydrochloride tablets n 157 not seen at an equivalent frequency among the placebo-treated patients n 147 were, in order of decreasing incidence nausea, dizziness, somnolence, headache, vomiting, syncope, fatigue, dyspepsia, viral infection, constipation, pain, increased sweating, asthenia, dependent leg edema, orthostatic symptoms, abdominal pain, pharyngitis, confusion, hallucinations, urinary tract infections, and abnormal vision.

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